Protein S : Recent topics and deficient mice

Generation and phenotypic analysis of protein S-deficient mice.

Protein S (PS) is an important natural anticoagulant with potentially multiple biologic functions. To investigate further the role of PS in vivo, we generated Pros(+/-) heterozygous mice. In the null (-) allele, the Pros exons 3 to 7 have been excised through conditional gene targeting. Pros(+/-) mice did not present any signs of spontaneous thrombosis and had reduced PS plasma levels and activ...

THROMBOSIS AND HEMOSTASIS Generation and phenotypic analysis of protein S–deficient mice

1Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; 2Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; 3Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; and 4Department of Molecular and Experimental Medic...

Recent topics in NMR imaging and MRI.

NMR and NMR imaging (MRI) are finding increasing use not only in the clinical and medical fields, but also in material, physicochemical, biological, geological, industrial and environmental applications. This short review is limited to two topics: (i) new techniques and pulse sequences and their application to non-clinical fields that may have clinical application; and (ii) new trends in MR con...

Hilbert ’ s fifth problem and related topics

Important Topics on Contemporary Total knee Arthroplasty: what Does Recent Literature Say?

In this Editorial I want to comment on eight recent articles that can help us to better understand still controversial matters related to total knee arthroplasty (TKA). In this Editorial I want to comment on eight recent articles that can help us to better understand still controversial matters related to total knee arthroplasty (TKA).